1. No. 8 Oklahoma at No. 10 West Virginia
This is shaping up to be a very competitive contest, and it will go a long way toward determining who wins the the Big 12 championship. It’s also an elimination game in the national tournament, with the winner having a good shot at the final spot in the playoff (and a date with Alabama). Despite having two terrible nonconference losses and only nominal opposition in the Big 12, Oklahoma (8-2 overall, 7-0 Big 12) has rebuilt its reputation in recent weeks. The defense has recovered against weaker competition, and QB Baker Mayfield has 17 TDs and only two picks in his last four games. West Virginia (8-1, 5-1) must continue to run the ball effectively to win – an area in which Oklahoma’s defense has been wildly inconsistent. But the Sooners may be vulnerable through the air. They allow nearly 300 yards per game. 8 p.m., WVEC
2. No. 20 Washington State at No. 12 Colorado
Anyone who says he predicted this would be a matchup of division leaders in the Pac-12 is either lying or Nostradamus. It helps that these teams have combined to play only two ranked opponents all season before today. Colorado (8-2 overall, 6-1 Pac-12) averages more than 200 rushing yards per game, and the Buffalos are likely to win if they hit that number again. If they don’t, the defense will have a hard time keeping up with the super-prolific passing attack that Washington State (8-2, 7-0) throws at you. 3:30 p.m., WVBT
3. No. 2 Ohio State at Michigan State
Ohio State (9-1, 6-1 Big Ten) is in an odd spot – second in the AP poll, second in the playoff rankings, yet unlikely to make the Big 10 title game or the playoff thanks to the loss to Penn State. The Buckeyes have to keep winning, and this will be a good warmup for the war against Michigan next week. Michigan State (3-7, 1-6) and its implosion is the strangest story of the year. Noon, ESPN
4. No. 15 USC at UCLA
Another strange story from this season is the resurrection of USC (7-3 overall, 6-2 Pac-12). The knives were out for coach Clay Helton when the Trojans were 1-3. Now, his team actually has a path – albeit a narrow on – to the playoff. Freshman QB Sam Darnold is the real deal, as he proved last week against Washington. 10:30 p.m., ESPN
5. No. 21 Florida at No. 16 LSU
Here’s all you need to know about the offenses in this game: Both starting quarterbacks transferred from Purdue, and neither was a starter back in August. If any game ever seemed destined to end 2-0, it’s this one. 10:30 p.m., ESPN
Also on the air
Iowa at Illinois, noon, BTN
Morgan State at Army, noon, CBSSN
UTSA at No. 23 Texas A&M, noon, TBA
Kansas State at Baylor, noon, ESPN2
Maryland at No. 19 Nebraska, noon, ESPNEWS
No. 6 Wisconsin at Purdue, noon, WVEC
Texas-San Antonio at Texas A&M, noon, ESPNU
No. 13 Oklahoma State at TCU, noon, FS1
Richmond at William & Mary, noon, CSN, WTVZ
Yale at Harvard, 12:30 p.m., CNBC
U.Va. at Georgia Tech, 12:30 p.m., WGNT, 850AM
Lafayette at Lehigh, 12:30 p.m., MASN
Norfolk St. at Hampton, 12:30 p.m., 1310AM, 91.1FM
Florida at LSU, 1 p.m., SEC
VMI at Wofford, 1:30 p.m., 1650AM
Bethune-Cookman vs. Florida. A&M, 2 p.m., ESPN Classic
Indiana at No. 4 Michigan, 3:30 p.m., ESPN
Missouri at Tennessee, 3:30 p.m., WTKR
No. 17 Florida State at Syracuse, 3:30 p.m., WVEC
Texas at Kansas, 3:30 p.m., ESPN2
No. 24 San Diego St. at Wyoming, 3:30 p.m., CBSSN
Texas Tech at Iowa State, 3:30 p.m., FS1
Va. Tech at Notre Dame, 3:30 p.m., WAVY, 790AM
Villanova at Delaware, 3:30 p.m., CSN
Buffalo at No. 14 W. Mich., 3:30 p.m., WTVZ, ESPNU
Navy at ECU, 4 p.m., ESPNEWS, 102.1FM
Austin Peay at Kentucky, 4:30 p.m., SEC
Old Dominion at Florida Atlantic, 5 p.m., 94.1FM
No. 5 Clemson at Wake Forest, 7 p.m., ESPN
Chattanooga at No. 1 Alabama, 7 p.m., ESPN2
Arkansas at Mississippi St., 7 p.m., ESPNU, 94.1FM
Marshall at FIU, 7 p.m., MASN, WTVZ
Arizona St. at No. 7 Washington, 7:30 p.m., WVBT
No. 9 Penn State at Rutgers, 8 p.m., BTN
Tulsa at Central Florida, 8 p.m., ESPNEWS
Mississippi at Vanderbilt, 8 p.m., SEC
N.C. Central at N.C. A&T, 10:30 p.m., ESPNU (tape-delayed)
Air Force at San Jose State, 10:30 p.m., CBSSN
New Mexico at Colorado State, 10:30 p.m., ESNP2
Also in the Top 25
No. 11 Utah vs. Oregon, 2 p.m.
No. 18 Auburn vs. Alabama A&M, 7:30 p.m.